品牌： Bioss

品名： Anti-TNF alpha肿瘤坏死因子-α/TNFα/TNF-α抗体

规格：100ul

研究领域 肿瘤 心血管 免疫学 信号转导 细胞凋亡 生长因子和激素 细胞因子

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Dog, Pig, Horse,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 17/26kDa

细胞定位 细胞膜 分泌型蛋白

性 状 Liquid

浓 度 1mg/ml

免 疫 原 KLH conjugated synthetic peptide derived from human TNF alpha:86-150/233 <Extracellular>

亚 型 IgG

纯化方法 affinity purified by Protein A

储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages,

and causes tumor necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and

tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units,

but shows a single 17 kDa band following SDS PAGE under non reducing conditions. TNF alpha is closely related to the 25

kDa protein Tumour Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes

cytolysis or cytostasis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has

little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other

actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils

and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being

evaluated in treatment of certain cancers and AIDS Related Complex.