货品编号： Bioss.bs-0349R-100ul

品牌： Bioss

品名： Anti-Histone H3/HIST3H3 (Nuclear Loading Control )组蛋白H3抗体

规格： 100ul

研究领域免疫学 细胞周期蛋白

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Pig, Cow, Rabbit, Fruit Fly,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量15kDa

细胞定位细胞核

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Histone H3:71-136/136

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes.

The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block

of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including

acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and

have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12,

15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have

a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of

histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.