货品编号： Bioss.bs-3710R 品 牌：Bioss 品 名：Anti-phospho-P53 (Thr18)磷酸化肿瘤抑制基因P53抗体 规 格：100ul 产品类型 磷酸化抗体 研究领域 肿瘤细胞生物免疫学信号转导转录调节因子 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1μg /testIF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 43kDa 细胞定位 细胞核细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated Synthesised phosphopeptide derived from human P53 around the phosphorylation site of Thr18:QE(p-T)FS 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍 This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The

encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis,

senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including

hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple

transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons

(PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].