货品编号： Bioss.bs-0431R-100ul

品牌： Bioss

品名： Anti-OPG骨保护蛋白/护骨素抗体

规格： 100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Cow,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量43kDa

细胞定位分泌型蛋白

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human OPG:221-300/401

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Osteoprotegerin (OPG, or osteoclastogenesis inhibitory factor) is a secretory glycoprotein belonging to

TNF receptor superfamily. Acts as decoy receptor for RANKL and thereby neutralizes its function in

osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis

seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act

as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

OPG acts as a soluble factor in the regulation of bone mass and may be beneficial in the treatment of osteoporosis

with increased osteoclast activity. OPG consists of 401 amino acids with a molecular weight of 44 kDa as a monomer

and 90 kDa as a disulphide-linked dimer.