货品编号： Bioss.bs-0501R

品牌： Bioss

品名： Anti-JNK1 + JNK3氨基末端激酶1/3抗体

规格： 100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量42kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human JNK1:201-300

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍JNK1(MAPK8) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple

biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation,

transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific

transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The

activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha

induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be

related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested

that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced

transcript variants encoding distinct isoforms have been reported. JNK1 is activated by threonine and tyrosine

phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. The JNK pathway is critically

involved in diabetes and levels are abnormally elevated in obesity. The cell-permeable JNK inhibitory peptide

may have promise as a therapeutic agent for diabetes.