货品编号Bioss.bs-0522R-100ul

品牌Bioss

品名Anti-CD45白细胞共同抗原CD45抗体

规格100ul

研究领域细胞生物 免疫学 神经生物学 信号转导 干细胞 转录调节因子 细胞表面分子 糖蛋白 细胞类型标志物 自然杀伤细胞 淋巴细胞 t-淋巴细胞 b-淋巴细胞 细胞膜蛋白

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Cow, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg/Test

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量143kDa

细胞定位细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human CD45:1210-1304/1304 <Cytoplasmic>

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are

known to be signaling molecules that regulate a variety of cellular processes including cell growth,

differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain,

a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to

receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to

be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction

with components of the antigen receptor complexes, or by activating various Src family kinases required for the

antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of

cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct

isoforms, have been reported. [provided by RefSeq, Jul 2008].