规 格： 100ul

研究领域 肿瘤细胞生物免疫学细胞凋亡线粒体抗体来源Rabbit克隆类型Polyclonal交叉反应Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,产品应用 WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1μg/TestIF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.分子量 26kDa细胞定位 细胞核细胞浆细胞膜线粒体性状 Liquid浓度 1mg/ml免疫原 KLH conjugated synthetic peptide derived from human Bcl-2:161-239/239亚型 IgG纯化方法 affinity purified by Protein A储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMed PubMed

产品介绍 The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell

death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor

withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into

its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive

amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates

apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of

Bcl-2(8).