货品编号： Bioss.bs-4597R 品 牌： Bioss 品 名： Anti-MMP-1基质金属蛋白酶-1抗体 规 格： 100ul 研究领域 肿瘤心血管免疫学信号转导细胞外基质 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 27/41/54kDa 细胞定位 细胞外基质 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human MMP-1:251-350/469 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases.

Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar

collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic

domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like

repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase,

stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from

the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown.

MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution,

angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis,

periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.