货品编号Bioss.bs-0737R

品牌Bioss

品名Anti-HIF-1 Alpha缺氧诱导因子1α /低氧诱导因子-1抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量92kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from middle of human HIF-1 Alpha:341-450/826

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced

oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1

is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as

the aryl hydrocarbon receptor nuclear translocator(ARNT). This gene encodes the alpha subunit of HIF-1.

Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with

nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.