货品编号： Bioss.bs-5274R 品 牌： Bioss 品 名：Anti-phospho-CDKN1A/p21 (Ser130)磷酸化p21蛋白抗体 规 格： 100ul 产品类型 磷酸化抗体 研究领域 肿瘤免疫学 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat, 产品应用 ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1ug/TestIF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 18kDa 细胞定位 细胞核细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated Synthesised phosphopeptide derived from human P21 around the phosphorylation site of Ser130:EG(p-S)PG 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍 This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2

or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled

by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to

a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor,

and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by

CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following

caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent

kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family

inhibits Cdk4 and Cdk6 specifically.