货品编号Bioss.bs-10397R

品牌Bioss

品名Anti-Factor VIII B chain凝血因子8/第八凝血因子/第八因子相关抗原抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量138kDa

细胞定位细胞外基质 分泌型蛋白

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Factor VIII B chain:1101-1200/2351

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor

VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated

form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein,

isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This

protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which

consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant

activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.