货品编号Bioss.bs-10900R

品牌Bioss

品名Anti-GAPDH-Loading Control3-磷酸甘油醛脱氢酶抗体

规格100ul

研究领域肿瘤 细胞生物 免疫学 信号转导 新陈代谢

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat,

产品应用WB=1:5000-20000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量38kDa

细胞定位细胞核 细胞浆 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原Recombinant human GAPDH full length protein:

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in

glycolysis. As well as functioning as a glycolytic enzyme in cytoplasm, recent evidence suggests that mammalian

GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule

bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last

decade a lot of data appeared concerning the role of GAPDH in different pathologies including prostate cancer

progression, programmed neuronal cell death, age related neuronal diseases, such as Alzheimer's and

Huntington's disease. GAPDH is expressed in all cells. It is constitutively expressed in almost all tissues at high

levels. There are however some physiological factors such as hypoxia and diabetes that increase GAPDH

expression in certain cell types. GAPDH molecule is composed of four 36kDa subunits.