货品编号Bioss.bs-1166R

品牌Bioss

品名Anti-ROCK1Rho相关蛋白激酶1抗体

规格100ul

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量158kDa

细胞定位细胞浆 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ROCK1:1001-1200/1354

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form

of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as

well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound

form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional

activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and

activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.