货品编号Bioss.bs-12577R

品牌Bioss

品名Anti-Phospho-Bcl2 (Ser87)磷酸化Bcl-2抗体

规格100ul

产品类型磷酸化抗体

研究领域肿瘤 细胞生物 信号转导 细胞凋亡 新陈代谢 线粒体

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Horse, Rabbit,

产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量26kDa

细胞定位细胞核 细胞浆 细胞膜 线粒体

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthesised phosphopeptide derived from human Bcl2 around the phosphorylation site of Ser87:AL(p-S)PV

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as

lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain

locus, is thought to be the cause of follicular lymphoma. Two transcript variants (alpha and beta) produced by

alternate splicing, differ in their C-terminal ends. BCL2 suppresses apoptosis in a variety of cell systems including

factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial

membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase

activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the

apoptosis-activating factor (APAF1). It can form homodimers, and heterodimers with BAX, BAD, BAK and BclX(L).

Heterodimerization with BAX requires intact BH1 and BH2 domains, and is necessary for anti-apoptotic activity.

Also interacts with APAF1, RAF1, TP53BP2, BBC3, BCL2L1 and BNIPL.