货品编号Bioss.bs-12856R

品牌Bioss

品名Anti-phospho-beta Catenin (Tyr333)磷酸化β-连环蛋白/β-连环素/β链接素抗体

规格100ul

研究领域肿瘤 细胞生物 神经生物学 信号转导 干细胞 细胞粘附分子

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量86kDa

细胞定位细胞核 细胞浆 细胞膜 细胞外基质

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthesised phosphopeptide derived from human beta Catenin around the phosphorylation site of Tyr333:YT(p-Y)EK

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs).

AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and

adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible

for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete.

Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon.

Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB),

and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.