货品编号Bioss.bs-1335R

品牌Bioss

品名Anti-Notch1跨膜受体蛋白Notch-1抗体

规格100ul

研究领域细胞生物 发育生物学 神经生物学 信号转导 干细胞 表观遗传学

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1µg/Test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量86/89/271kDa

细胞定位细胞核 细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human C-terminal sequence of Notch 1 extracellular truncation and Notch 1

intracellular domain :2101-2300/2555

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share

structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like

(EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members

play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network

is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically

adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular

signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified

in human, but precise interactions between these ligands and the human notch homologues remain to be determined.

This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein

functions as a receptor for membrane bound ligands, and may play multiple roles during development.