货品编号： Bioss.bsm-33411M 品 牌： Bioss 品 名：Anti-Bcl-2Bcl-2单克隆抗体 规 格： 100ul 研究领域 肿瘤心血管细胞生物信号转导细胞凋亡新陈代谢线粒体 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 3F12 交叉反应 Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,Guinea Pig, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500ICC=1:100（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 26kDa 细胞定位 细胞核细胞浆细胞膜线粒体 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human Bcl-2:51-150/239 亚型 IgG1 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks

cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth

factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer

insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),

has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression

of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the

death repressor activty of Bcl-2(8).