货品编号： Bioss.bsm-33196M 品 牌： Bioss 品 名：Anti-CREB-1环腺苷酸应答元件结合蛋白单克隆抗体 规 格： 100ul 研究领域 信号转导 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 6B4 交叉反应 Human,Mouse, 产品应用 WB=1:500-1000IHC-P=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 37kDa 细胞定位 细胞核 性状 Liquid 浓度 1mg/ml 免疫原 Recombinant human CREB-1: 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP

response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters,

hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation

of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB

will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding

protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to

play an important role in learning and memory. CREB knock out mice show diminished learning ability.