货品编号： Bioss.bsm-33224M 品 牌： Bioss 品 名：Anti-GRP78/Bip葡萄糖调节蛋白78单克隆抗体 规 格： 100ul 研究领域 肿瘤细胞生物免疫学 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 10A3 交叉反应 Human,Rat, 产品应用 WB=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 78kDa 细胞定位 细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human GRP78/Bip: 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍 The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78

is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized

secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing

their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved

sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose

regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be

necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported

to be mediated by a KDEL receptor.