货品编号： Bioss.bsm-33278M 品 牌： Bioss 品 名：Anti-AKT蛋白激酶B单克隆抗体100ul 规 格： 100ul 研究领域 肿瘤细胞生物神经生物学信号转导细胞凋亡激酶和磷酸酶 抗体来源 Mouse 克隆类型 Monoclonal 克隆号 10D8 交叉反应 Human, 产品应用 WB=1:500-1000ELISA=1:500-1000ICC=1:100 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 56kDa 细胞定位 细胞核细胞浆细胞膜 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human AKT: 亚型 IgG 纯化方法 affinity purified by Protein G 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts.

AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations

in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing

nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-

independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic

machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been

found for this gene. [provided by RefSeq, Jul 2011]