货品编号： bioss.bs-2188R-10ul 品 牌：bioss 品 名：3-磷酸甘油醛脱氢酶（内参）抗体 试用装 规 格： 10ul 产品描述： Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis.

As well as functioning as a glycolytic enzyme in cytoplasm, recent evidence suggests that mammalian GAPDH is also

involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase

activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of data appeared concerning

the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age

related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. It is constitutively

expressed in almost all tissues at high levels. There are however some physiological factors such as hypoxia and diabetes

that increase GAPDH expression in certain cell types. GAPDH molecule is composed of four 38kDa subunits.

Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and

nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and

apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear

target proteins such as SIRT1, HDAC2 and PRKDC. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in

glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-

glyceroyl phosphate.