货品编号： 博奥森.bs-6669R 品 牌：博奥森 品 名：DNA结合抑制因子4抗体 规 格： 100ul 产品描述： 研究领域 细胞生物信号转导干细胞表观遗传学 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, (predicted: Mouse,Rat,Dog,Pig,) 产品应用 ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 18kDa 细胞定位 细胞核 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human ID4:61-160/161 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed

产品介绍 Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (1–3), Id2 (4), Id3 and Id4 (5). They

are ubiquitously expressed and dimerize with members of the class A and B HLH proteins (1–5). Due to the absence

of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate

DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-

specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12

and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been

shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id

mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth

factor stimulation.