货品编号：博奥森.bs-1419R

品牌：博奥森

品名：黑皮质素-1受体抗体

规格：50ul

研究领域细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, (predicted: Mouse, Rat, )

产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1µg/Test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量35kDa

细胞定位细胞膜

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from mouse MC-1R:271-317/317 <Cytoplasmic>

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍This intronless gene encodes the receptor protein for melanocyte -stimulating hormone (MSH). The encoded protein, a seven

pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and

black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which

leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage

by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin

synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma

skin cancer. Over30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this

gene is an important component in determining normal human pigment variation.