货品编号：博奥森.bsm-10832m

品牌：博奥森

品名：S100B蛋白单克隆抗体

规格：50ul

研究领域肿瘤 细胞生物 神经生物学 细胞周期蛋白 细胞分化

抗体来源Mouse

克隆类型Monoclonal

克 隆 号1C6

交叉反应Human, Mouse, Rat,

产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量10kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原Recombinant human S100B protein: 2-92/92aa (N-6x His-Tag)

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍S100 beta is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are

localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular

processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located

as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in neurite extension,

proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC mediated phosphorylation, astrocytosis and

axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this

gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease,

Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.