货品编号：Bioss.bs-0167R

品牌：Bioss

品名：Apolipoprotein E 载脂蛋白E抗体

规格：50ul

研究领域肿瘤 心血管 细胞生物 神经生物学 信号转导 细胞凋亡 转录调节因子 合成与降解

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Rat, (predicted: Mouse, )

产品应用WB=1:500-2000 ELISA=1:5000-10000

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量32kDa

细胞定位分泌型蛋白

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from mouse Apo E:211-311/311

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells

and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE exists in three major

isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and

E4, E2 exhibits the lowest receptor binding affinity. Defects in ApoE are a cause of hyperlipoproteinemia type III due

to increased plasma cholesterol and triglycerides levels which are the consequence of impaired clearance of chylomicron

and VLDL remnants.

Summary: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the

circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds

to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich

lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in

apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased

plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

[provided by RefSeq, Jul 2008].