货品编号： Bioss.bs-10377R 品牌：Bioss 品名：Rabbit Anti-Galectin-3 antibody 规格：100ul

产品描述： background: This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family

have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat

domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal

domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm

and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion

and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].

Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial

cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.

In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and

adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Subunit: Probably forms homo- or heterodimers. Interacts with DMBT1. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with

LGALS3BP, LYPD3, CYHR1 and UACA.