货品编号：博奥森.bs-9449R

品牌：博奥森

品名：甲基双加氧酶TET2抗体

规格：100ul

研究领域肿瘤 细胞生物 免疫学

抗体来源Rabbit

克隆类型Polyclonal

交叉反应(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, )

产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量224kDa

细胞定位细胞核 细胞浆 细胞膜 细胞外基质 分泌型蛋白

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human TET2:1101-1300/2002

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍

TET2 is a 2,002 amino acid protein that is expressed in a variety of tissues, including brain, kidney, heart, lung, muscle and stomach, and

exists as three alternatively spliced isoforms. Murine TET2 is also known as protein Ayu17-449 and is thought to play a role in proper kidney

development and overall kidney function, as well as in hormone secretion throughout the body. The gene encoding human TET2 maps to

chromosome 4 and the gene encoding mouse TET2 maps to chromosome 3. Chromosome 4 encodes nearly 6% of the human genome and

has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the

genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic

kidney disease. Murine chromosome 3 houses over 1,300 genes, some of which express alcohol dehydrogenases (ADHs), sodium channel

modifiers (SCNMs), interleukins (ILs) and Insulin receptor-related (IRR) proteins. Defects in chromosome 3-localized genes are associated with

hereditary congenital facial paresis (HCFP), increased susceptibility to spontaneous colitis, HIV-1-associated nephropathy, decreased renal vascular

health and malignant sporadic pancreatic endocrine tumors.