货品编号：博奥森.bs-4311R

品牌：博奥森

品名：髓系细胞触发受体2抗体

规格：100ul

研究领域肿瘤 细胞生物 染色质和核信号 信号转导 转录调节因子 表观遗传学

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Mouse, Rat, (predicted: Human, Dog, Cow, Horse, Rabbit, )

产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量28kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human NR0B2:31-130/257

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍SHP is an orphan nuclear receptor containing the dimerization and ligand-binding domains found in other nuclear receptors,

but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues, including fetal liver and adrenal gland, as well as adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage

cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARg. SHP interacts with nuclear receptors,

including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a

negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct

antagonism of coactivator function through competition and possibly transrepression via recruitment of putative corepressors.

In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NFkB, suggesting that SHP is a modulatory

component in the regulation of the transcriptional activities of NFkB. Lastly, negative feedback regulation of a hepatic bile acid

transporter, NTCP, is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated

damage in cholestatic conditions.