博奥森 bs-18248R Rabbit Anti-MYL2 antibody 50ulBioss-耗材-金山科研平台 Thermo Fisher官网Nunc、QSP、Nalgene、Invitrogen、Gibco耗材试剂授权一级代理

博奥森 bs-18248R Rabbit Anti-MYL2 antibody 50ulBioss

货品编号：博奥森bs-18248R

品牌：博奥森

品名： Rabbit Anti-MYL2 antibody

规格： 50ul

产品编号	bs-18248R
英文名称	MYL2
中文名称	心脏肌球蛋白轻链2抗体
别名	Cardiac myosin light chain-2; Cardiac ventricular myosin light chain 2; CMH10; MLC 2v; MLC-2; MLC-2v; MLC2; MLRV_HUMAN; MYL 2; MYL2; Myosin light chain 2 regulatory cardiac slow; Myosin light polypeptide 2 regulatory cardiac slow; Myosin regulatory light chain 2 ventricular cardiac muscle isoform; Myosin regulatory light chain 2 ventricular/cardiac muscle isoform; Regulatory light chain of myosin; RLC of myosin; Slow cardiac myosin regulatory light chain 2; ventricular/cardiac muscle isoform.
研究领域	心血管细胞生物信号转导干细胞
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, (predicted: Human,Rat,Chicken,Pig,Rabbit,)
产品应用	WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
分子量	20kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Cardiac ventricular myosin light chain 2:11-110/166
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]Function:Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.Subunit:Myosin is a hexamer of 2 heavy chains and 4 light chains.Tissue Specificity:Expressed in fetal and adult skeletal muscle.Post-translational modifications:N-terminus is methylated by METTL11A/NTM1.DISEASE:Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.Similarity:Contains 3 EF-hand domains.SWISS:P10916Gene ID:4633Database links: Entrez Gene: 505519Cow Entrez Gene: 403614Dog Entrez Gene: 4633Human Entrez Gene: 17906Mouse Entrez Gene: 363925Rat Omim: 160781Human SwissProt: Q3SZE5Cow SwissProt: P10916Human SwissProt: P51667Mouse SwissProt: P08733Rat Unigene: 48942Cow Unigene: 75535Human Unigene: 1529Mouse Unigene: 37176Rat Unigene: 6534Rat Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Sample:Heart (Mouse) Lysate at 40 ugPrimary: Anti-MYL2 (bs-18248R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 20 kDObserved band size: 20 kD

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博奥森 bs-18248R Rabbit Anti-MYL2 antibody 50ulBioss

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