博奥森.bS-1684R C-SKI抗体 50ul Bioss-耗材-金山科研平台 Thermo Fisher官网Nunc、QSP、Nalgene、Invitrogen、Gibco耗材试剂授权一级代理

博奥森.bS-1684R C-SKI抗体 50ul Bioss

货品编号：博奥森.bS-1684R

品牌：博奥森

品名： C-SKI抗体

规格： 50ul

产品编号	bs-1684R
英文名称	SKI
中文名称	C-SKI抗体
别名	C-SKI; v-SKI; Sloan-kettering viral oncogene homolog; Avian sarcoma viral (v ski) oncogene homolog; C oncogene; C ski; Ski oncogene; Ski oncoprotein; SKV; v ski avian sarcoma viral oncogene homolog; v ski sarcoma viral oncogene homolog; v-ski sarcoma viral oncogene homolog; SKI_HUMAN.
研究领域	肿瘤转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Horse,)
产品应用	WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
分子量	80kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human C-SKI:551-650/728
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.Function:May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.Subunit:Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes.Subcellular Location:Nucleus.Similarity:Belongs to the SKI family.SWISS:P12755Gene ID:6497Database links: Entrez Gene: 6497Human Entrez Gene: 20481Mouse Omim: 164780Human SwissProt: P49140Chicken SwissProt: P12755Human SwissProt: Q60698Mouse Unigene: 656507Human Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.SKI又称SKI、SKV，经研究发现SKI蛋白是刺激和诱发肿瘤生长导致癌症的关键蛋白质之一，SKI蛋白主要通过阻止TGF-β蛋白发挥作用,当TGF-β蛋白的信号传导被SKI蛋白阻断后，细胞就可能加速增值、生长，最终导致癌症发生。有研究表明：c-ski可调节多种核因子的转录活性,参与神经系统发育、造血细胞的增殖和分化、肿瘤发生、组织再生等多种生理病理过程，更详细的作用机制还在进一步研究之中。

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博奥森.bS-1684R C-SKI抗体 50ul Bioss

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