代理PD 0325901 MEK抑制剂 2mg TGF-beta家族 现货


产品英文名称:PD 0325901

产品中文名称:PD 0325901 MEK抑制剂

PD 0325901 is a selective inhibitor against purified MEK, exhibiting a Ki of 1 nM against activated MEK1 and MEK2. It has been shown that 1 µM PD0325901 combined with 3 µM CHIR99021 (2i) prevents cell differentiation and sustains self-renewal of murine embryonic stem cells. N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE

Ref: Barret, S.D., Bridges, A.J., Dudley, D.T., et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett 18 6501-6504, 2008. Ying, Q., Wray, J., Nichols, J., et al. The ground state of embryonic stem cell self-renewal. Nature 453 519-524, 2008.

Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity: Not determined.

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