货品编号： Signalchem.A16-10G-10

品牌： Signalchem

品名：AKT1, Active

规格： 10 ug

Product Details Description:Recombinant full-length human AKT1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. Species:Human Tag:GST tag Expression System:Sf9 insect cells using baculovirus Sequence:Full Length Genbank Number:NM_005163 Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet. Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation

and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications :Kinase Assay, Western Blot Molecular Weight :~85 kDa Gene Aliases :PKB; RAC; PRKBA; MGC99656; RAC-ALPHA Scientific Background :AKT1/PKBα is a serine/threonine kinase that belongs to the AKT family. AKT1 is activated in cells in response

to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription,

survival, cell proliferation, angiogenesis, and cell motility (1). AKT1 is frequently overexpressed and active in many types of human cancers

including cancers of colon, breast, brain, pancreas and prostate as well as lymphomas and leukemias (2). References : 1. Coffer, PJ. et al: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998 Oct 1;

335 (Pt 1): 1-13. 2. Anderson, KE. et al: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol.

1998 Jun 4;8(12): 684-91.