货品编号： Signalchem.A17-10G-10

品牌： Signalchem

品名：AKT2, Active

规格： 10 ug

Product Details Description:Recombinant full-length human AKT2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. Species:Human Tag:GST tag Expression System:Sf9 insect cells using baculovirus Sequence:Full Length Genbank Number:NM_001626 Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet. Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation

and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications :Kinase Assay, Western Blot Molecular Weight :~85 kDa Gene Aliases :PRKBB; PKBBETA; RAC-BETA Scientific Background :AKT2 or Protein Kinase B β (PKBβ) is a serine/threonine kinase that is a member of the AKT family. AKT2 like

the other AKT members is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix

components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility. The PI3K

generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of AKT2 to the plasma

membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1). References : 1. Coffer, PJ. et al: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998 Oct 1;

335 ( Pt 1):1-13. 2. Anderson, KE. et al: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol.

1998 Jun 4;8(12): 684-91.