货品编号： Invitrogen.PA1-511A

品牌： Invitrogen

品名： Glucocorticoid Receptor Polyclonal Antibody

规格： 50 µg

Product Specific Information PA1-511A detects glucocorticoid receptor (GR) from human, mouse and rat tissues. PA1-511A has been successfully used in Western blot, immunocytochemistry, immunofluorescence, and immunohistochemistry

procedures. By Western blot, this antibody detects an ~97 kDa protein representing GR from rat liver extract. Immunocytochemical

staining of GR in HeLa cells using PA1-511A results in cytoplasmic staining in the absence of ligand, and nuclear staining after

hormone administration.

The PA1-511A immunogen is a synthetic peptide corresponding to residues D(346) Q K P I F N V I P P I P V G S E N W N R C(367)

from human GR. The PA1-511A immunizing peptide (Cat. # PEP-001) is available for use in neutralization and control experiments.

Background/Target Information Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA

sequences following activation by the appropriate hormone. Glucocorticoids are a family of steroids necessary for the regulation of energy

metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocoticoid

receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to

contain glucocorticoid receptor.