货品编号： Invitrogen.PA5-36625

品牌： Invitrogen

品名： Phospho-Bcl-2 (Thr56) Polyclonal Antibody

Product Specific Information This antibody detects endogenous protein at a molecular weight of 26 kDa. Purity is >95% by SDS-PAGE.

Background/Target Information Bcl-2 is one among many key regulators of apoptosis which are essential for proper development, tissue homeostasis and protection

against foreign pathogens. Human Bcl-2 is a 26 kDa, membraneassociated, anti-apoptotic oncoprotein that can promote cell survival

through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xL, Mcl-1, Bcl-w and A1,

or the death agonists Bax, Bak, Bik, Bad and BID. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing

and phosphorylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through

stabilization of the mitochondrial membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.