货品编号： Signalchem.A28-18G-10 品牌： Signalchem 品名： AURORA A, Active 规格： 10ug
产品描述：
Description:Recombinantfull-lengthhumanAURORAAwasexpressedbybaculovirusinSf9cellsusinganN-terminalGSTtag.Species:Human Tag:GSTtag ExpressionSystem:Sf9insectcellsusingbaculovirus Sequence:FullLength GenbankNumber:NM_003600 SpecificActivity:SampleKinaseActivityPlot.Forspecificinformationonagivenlot,seerelatedtechnicaldatasheet. Purity:SamplePurityData.Forspecificinformationonagivenlot,seerelatedtechnicaldatasheet. Storage,StabilityandShipping:Storeproductat–70oC.Foroptimalstorage,aliquottargetintosmallerquantitiesaftercentrifugation
andstoreatrecommendedtemperature.Formostfavorableperformance,avoidrepeatedhandlingandmultiplefreeze/thawcycles. Applications:KinaseAssay,WesternBlot MolecularWeight:~72kDa GeneAliases:AURKA,AIK,ARK1,AURA,BTAK,STK6,STK7,STK15,AURORA2,MGC34538ScientificBackground:AURORAAbelongstoamultigenicfamilyofmitoticserine/threoninekinaseswhichareinvolvedinthecontrolof
chromosomesegregation.AURORAAisinvolvedincentrosomeseparation,duplicationandmaturationaswellasinbipolarspindleassembly
andstability(1).AURORAAisexpressedandactiveatthehighestlevelduringG2-Mphaseofthecellcycle.OverexpressionofAURORAAhas
beenfoundtobecorrelatedwiththegradeofvarioushumansolidtumours.EctopicAURORAAoverexpressioninanyculturecelllineleadsto
polyploidyandcentrosomeamplification(2). References: 1.Dutertre,S.etal:Ontheroleofaurora-Aincentrosomefunction.Oncogene.2002Sep9;21(40):6175-83. 2.Katayama,H.etal:TheAurorakinases:roleincelltransformationandtumorigenesis.CancerMetastasisRev.2003Dec;22(4):451-64. Formulation:50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.
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