Signalchem A28-18G-10 AURORA A, Active 10ugSignalChem-耗材-金山科研平台 Thermo Fisher官网Nunc、QSP、Nalgene、Invitrogen、Gibco耗材试剂授权一级代理

Signalchem A28-18G-10 AURORA A, Active 10ugSignalChem

货品编号： Signalchem.A28-18G-10 品牌： Signalchem 品名： AURORA A, Active 规格： 10ug

产品描述：

Description:Recombinantfull-lengthhumanAURORAAwasexpressedbybaculovirusinSf9cellsusinganN-terminalGSTtag.Species:Human Tag:GSTtag ExpressionSystem:Sf9insectcellsusingbaculovirus Sequence:FullLength GenbankNumber:NM_003600 SpecificActivity:SampleKinaseActivityPlot.Forspecificinformationonagivenlot,seerelatedtechnicaldatasheet. Purity:SamplePurityData.Forspecificinformationonagivenlot,seerelatedtechnicaldatasheet. Storage,StabilityandShipping:Storeproductat–70oC.Foroptimalstorage,aliquottargetintosmallerquantitiesaftercentrifugation

andstoreatrecommendedtemperature.Formostfavorableperformance,avoidrepeatedhandlingandmultiplefreeze/thawcycles. Applications:KinaseAssay,WesternBlot MolecularWeight:~72kDa GeneAliases:AURKA,AIK,ARK1,AURA,BTAK,STK6,STK7,STK15,AURORA2,MGC34538ScientificBackground:AURORAAbelongstoamultigenicfamilyofmitoticserine/threoninekinaseswhichareinvolvedinthecontrolof

chromosomesegregation.AURORAAisinvolvedincentrosomeseparation,duplicationandmaturationaswellasinbipolarspindleassembly

andstability(1).AURORAAisexpressedandactiveatthehighestlevelduringG2-Mphaseofthecellcycle.OverexpressionofAURORAAhas

beenfoundtobecorrelatedwiththegradeofvarioushumansolidtumours.EctopicAURORAAoverexpressioninanyculturecelllineleadsto

polyploidyandcentrosomeamplification(2). References: 1.Dutertre,S.etal:Ontheroleofaurora-Aincentrosomefunction.Oncogene.2002Sep9;21(40):6175-83. 2.Katayama,H.etal:TheAurorakinases:roleincelltransformationandtumorigenesis.CancerMetastasisRev.2003Dec;22(4):451-64. Formulation:50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.

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Signalchem A28-18G-10 AURORA A, Active 10ugSignalChem

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