货品编号： Invitrogen.PA516914 品牌： Invitrogen 品名： beta Actin Polyclonal Antibody 规格： 500UL

产品描述 Product Specific Information PA5-16914 targets Actin Beta in IHC (P) and WB applications and shows reactivity with Bovine, Canine, Chicken, Drosophila,

Feline, Guinea Pig, Human, Leech, mouse, Ovine, Porcine, Rabbit, and Rat samples.

The PA5-16914 immunogen is synthetic peptide corresponding to N-terminus of human beta-actin.

Background/Target Information Beta actin is one of six actin isoforms which have been identified. Beta actin is a non-muscle cytoskeletal protein in all human

cell types and is involved in cell motility, structure, and integrity. There are six different actin isoforms in human. The beta isoform

of actin, along with gamma actin, coexist in most cell types as components of the cyto-skeleton. Beta actins are cytoplasmic

proteins ubuquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament

(F-actin) in the form of two stranded helix. Actins are highly conserved proteins that are involved in cell motility, structure and

integrity. Because beta actin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays

involving protein detection, such as Western blotting. Antibodies to beta-actin provide a specific and useful tool in studying the

intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton.