货品编号： 博奥森.bs-1278R 品牌：博奥森 品名：8-OHdG/DNA/RNA Damage8-羟基脱氧鸟苷/DNA/RNA Damage抗体 规格：100ul 产品描述：

background: 8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are

formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence

to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases

in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis,

inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.

Function: Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive

oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an

important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1.