货品编号： 博奥森.bs-23788R 品牌：博奥森 品名：NG2黑色素瘤硫酸软骨素蛋白多糖4抗体 规格：100ul 产品描述：

background: NG2 (also known as melanoma-associated chondroitin sulfate proteoglycan 4, MCSP, MCSPG, MSK16 and MEL-CSPG)

stabilizes cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes.

NG2 may facilitate primary melanoma progression by enhancing the activation of key signaling pathways important for tumor

invasion and growth. Threonine 2256 phosphorylation of rat NG2 (Threonine 2252 phosphorylation of human NG2) leads to

redistribution of NG2 on the surface of astrocytomas, polarization of the cell and a significant increase in cell motility. NG2 acts

as a co-receptor for spreading and focal contact formation in association with Alpha 4 Beta1 integrin in malignant melanoma

cells. NG2 is present on blood vessels throughout the rat embryo. Microvessels within the rat CNS express NG2 on endothelial

cells, and outside the CNS, NG2 is present on smooth muscle cells. NG2 is a novel marker for epidermal stem cells that

contributes to their patterned distribution by promoting stem cell clustering.

Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular

morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor

for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus

growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion

of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing

plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic

C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase

activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade

through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.