货品编号： eBioscience.12-1631-80 品牌：eBioscience 品名：CD163 Monoclonal Antibody (TNKUPJ), PE, eBioscience™ 规格：25 µg

Product Specific Information Description: This TNKUPJ monoclonal antibody recognizes mouse CD163. CD163 is a 130kDa surface receptor

expressed by certain subsets of tissue macrophages, including splenic red pulp macrophages, Kupffer cells, intestinal

lamina propria macrophages and a small fraction of peritoneal macrophages. In contrast to human blood monocytes,

mouse monocytes do not express CD163. Also, unlike human CD163, mouse CD163 is not as readily induced by M2

polarizing cytokines, and it is not a good marker of M2 macrophages. No common cell lines of monocytic or macrophage

origin express mouse CD163. In humans, CD163 has been shown to be proteolytically cleaved and shed from the cell

surface, and it acts as a soluble anti-inflammatory factor.

This TNKUPJ antibody will detect CD163 on fixed and permeabilized cells allowing for staining of the intracellular pool of

this receptor. Although CD163 is relatively stable to collagenase digestion, aggressive tissue dissociation protocols might

potentially decrease the amount of surface CD163. In these cases intracellular detection is recommended.

Applications Reported: This TNKUPJ antibody has been reported for use in flow cytometric analysis.