货品编号： 博奥森.bs-23387R 品牌：博奥森 品名：PER2/Period circadian protein 2节律蛋白2抗体 规格： 100ul

产品描述： background: PER2, a mammalian homologue of the Drosophila period gene, shares a 40% homology with PER1

including the protein dimerization PAS domain. PER2 is a circadian regulator that may act as a transcription

factor. It behaves as a negative element in circadian transcriptional loop. PER2 does not appear to bind DNA,

suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hour rhythm in the suprachiasmatic

nucleus (SCN) and the whole eyes. Oscillations are maintained under constant darkness and are responsive to

changes of the light/dark cycles. There is a 4 hour time delay between PER1 and PER2 oscillations. The

expression rhythms appear to originate from retina.

Function: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative

element in the circadian transcriptional loop. Influences clock function by interacting with other circadian

regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK NPAS2-BMAL1