产品描述： background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family

members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces

pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit

of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity

of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins

and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate,

and thus regulate the activity of, tumor suppressor protein Rb.

Function: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition.

Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1

kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell

differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation

of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of

the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development.

Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes,

changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced

motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription

transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the

proliferation of beta-cells in pancreatic islets of Langerhans.