货品编号： Bioss.bs-1513R 品牌：Bioss 品名：Rabbit Anti-EpCAM antibody 规格：100ul

产品描述： background: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I

membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and

functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for

immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

[provided by RefSeq, Dec 2008]

Function: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial

lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against

mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression

of FABP5, MYC and cyclins A and E.

Subunit: Monomer. Interacts with phosphorylated CLDN7.

Subcellular Location: Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Co-localizes with

CLDN7 at the lateral cell membrane and tight junction.

Tissue Specificity: Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly

diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on

mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.