货品编号： Bioss.bs-7620R 品牌：Bioss 品名：Rabbit Anti-Band3 antibody 规格：100ul

产品描述： background: Band 3, also designated AE1, is an erythrocyte membrane glycoprotein that contributes to cell stuctural integrity and

mediates exchange of chloride and bicarbonate across the phospholipid bilayer. The diverse functions of the approximately

900 amino acid protein are mediated by two distinct domains. The amino terminal domain, also known as cdb3 for

cytoplasmic domain of erthrocyte membrane band 3, acts as an attachment site for the erythrocyte skeleton by binding ankyrin.

The carboxy-terminal, membrane-associated domain carries out exchange transport of anions. Degradation of band 3 can

generate an aging antigen known as senescent cell antigen, or SCA, which is expressed on old cells and marks them for removal

by the immune system. An isoform of band 3, which lacks the first 65 amino acids and does not bind ankryin, is expressed in kidney.

Function: Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain

mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for

cytoskeletal proteins, glycolytic enzymes, and hemoglobin.

Subunit:

A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric. Interacts (via cytoplasmic N-terminus domain)

with ANK1 (via N-terminus ANK repeats).