货品编号： Bioss.bs-10549R 品牌：Bioss 品名：Rabbit Anti-CD55 antibody 规格：100ul

产品描述： background: This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is

also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay,

disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute

the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been

identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma

component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels.

Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent

C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b

polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb

and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.

Subunit: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Binds to coxsackievirus A21, coxsackieviruses

B1, B3 and B5, human enterovirus 70, human echoviruses 6, 7, 11, 12, 20 and 21 capsid proteins and acts as a receptor for these

viruses.