产品描述： background: DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation

in prostate and breast cancers. It also interacts with MAP3K5 to disrupt the association of MAP3K5 with the inhibitory

14-3-3 complex.

Function: Functions as a Ras GTPase-activating protein (By similarity). Through its interaction with MAP3K5 disrupts the association

of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits

CHUK-NF-kappa-B signaling. May act as a tumor suppressor gene.

Subunit: Interacts with MAP3K5, preferentially with its 'Ser-966' dephosphorylated form. On plasma membrane, exists in an inactive

form complexed with TNFR1. In response to TNF, dissociates from TNFR1 complex, tranlocates to cytoplasm and forms part

of an intracellular signaling complex comprising TRADD, RALBP1, TRAF2 and MAP3K5. Binding to MAP3K5 is induced by

TNF. Interacts with DAB1 and DAB2 (By similarity). Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in

response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis.

Subcellular Location: Membrane. Cytoplasm. Note=Translocates to the cytoplasm in response to TNF.

Tissue Specificity: Low expression in prostate. Down-regulated in prostate cancer.

DISEASE: Note=A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)

(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain.