产品描述： background: This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin

microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity

of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport

of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a

number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant,

pulverulent cataract.[provided by RefSeq, Jun 2009]

Function: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is

attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.

Subunit: Homopolymer assembled from elementary dimers. Interacts with HCV core protein. Interacts with LGSN and SYNM. Interacts

(via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with SLC6A4. Interacts with STK33. Interacts with LARP6.

Interacts with RAB8B (By similarity).

Subcellular Location: Cytoplasm.

Tissue Specificity: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines.

Expressed in many hormone-independent mammary carcinoma cell lines.

Post-translational modifications: Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin. One of the most prominent

phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin

filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5

during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.