货品编号： bioss.bs-3737R 品牌：bioss 品名：Rabbit Anti-Phospho-PPAR Gamma (Ser112) antibody

规格： 100ul

产品描述： background: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors.

PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various

genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by

this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated

in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced

transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the

receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls

the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.