货品编号： bioss.bs-4055R 品牌：bioss 品名：Rabbit Anti-phospho-PPAR alpha (Ser12) antibody

规格：100ul

产品描述： background:

Peroxisome proliferators are nongenotoxic carcinogens which are purported to exert their effect on cells through their

interaction with members of the nuclear hormone receptor family, termed Peroxisome Proliferator Activated Receptors

(PPARs). Nuclear hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific

genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs

are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids.

It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 A6

(CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including

linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride

levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes

involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte

apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha

to form a transcriptionally competent complex.