货品编号： sigma.p0913-50mg 品牌：sigma 品名：Polyinosinic–polycytidylic acid sodium salt γ-irradiated (Sigma) 规格：50mg

产品描述：

Biochem/physiol Actions Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis.

Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation,

and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-

associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate generators of stable mature

dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability

to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor

immune responses against a peptide-based vaccine.